Title: Cayos Zapatilla Vacation Packages 2026 from $618 | Expedia.com

[Cayos Zapatilla Travel Guide](https://expedia.com/Cayos-Zapatilla.dx6286134)[Hotels in Cayos Zapatilla](https://expedia.com/Cayos-Zapatilla-Hotels.d6286134.Travel-Guide-Hotels)[Vacation Rentals in Cayos Zapatilla](https://expedia.com/Cayos-Zapatilla-Vacation-Rentals.d6286134.Travel-Guide-VacationRentals)[Flights to Cayos Zapatilla](https://expedia.com/Cheap-Flights-To-Cayos-Zapatilla.d6286134.Travel-Guide-Flights)[Car Rentals in Cayos Zapatilla](https://expedia.com/Car-Rentals-In-Cayos-Zapatilla.d6286134.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6286134/443bad9e-c57b-4b6d-aec8-29e5bf3e9898.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Cayos Zapatilla Vacations from $618

## Book a Hotel + Flight or Car together to unlock savings

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## The Latest Cayos Zapatilla vacation packages

Price found within the past 48 hours. Click for updated prices.

![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Mahogany Suites

$618

per person

Apr 19 - Apr 24

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

10/10 Exceptional! (1 review)

Excellent apartment on a golf resort. 5 Star.

Reviewed on Jan 28, 2026

![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,029

per person

Apr 19 - Apr 24

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (1,002 reviews)

The room had no window to the outside it instead had a large window into an interior hall. Maid service was inconsistent. Breakfast was not a good value.

Reviewed on Feb 5, 2026

![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Megapolis Hotel Panamá

San Francisco

Save 100% on your flight

$882

per person

Apr 28 - May 3

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to Panama City (PTY)

8.4/10 Very Good! (1,204 reviews)

Nice hotel. Friendly staff

Reviewed on Feb 9, 2026

![Villa Botero By Casa Mojito B&B](https://images.trvl-media.com/lodging/12000000/11930000/11927200/11927153/393d35f8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Villa Botero By Casa Mojito B&B

$944

per person

Mar 29 - Apr 4

found 20 hours ago

Roundtrip flight included

New York (NYC) to Panama City (PTY)

9.8/10 Exceptional! (60 reviews)

We stayed one night and it exceeded our expectations. The owners were incredibly friendly and easy to contact, making us feel right at home. Everything was spotless, and the atmosphere was warm and inviting. The homemade breakfast was a highlight—absolutely delicious and full of flavor. We will stay again longer next time.

Reviewed on Jan 22, 2026

![Dreams Playa Bonita Panama - All Inclusive](https://images.trvl-media.com/lodging/13000000/12450000/12445600/12445554/7c338453_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Dreams Playa Bonita Panama - All Inclusive

$1,497

per person

Mar 14 - Mar 18

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

7.4/10 Good! (1,002 reviews)

It was a wonderful stay with wonderful people

Reviewed on Feb 7, 2026

Don't see what you're looking for?

See all available trips from Columbus to Cayos Zapatilla

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-10/2026-03-17/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

## Cayos Zapatilla Hotel Deals

![Tropical Suites Hotel](https://images.trvl-media.com/lodging/4000000/3610000/3608200/3608197/0dde6095_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Tropical Suites Hotel

First Street, Bocas Town Bocas del Toro 

Fully refundableReserve now, pay when you stay

$233 nightly

$257 total

Mar 1 - Mar 2

Total with taxes and fees

9.2/10 Wonderful! (299 reviews)

Very clean room. Staff are super accommodating, polite and friendly. It is a bit pricey for the room We ate elsewhere as it is expensive to eat and drink here. Toilet seat needs attention. Our coffee maker sometimes worked and sometimes did not. We had an ocean view. Nice pool area.

Reviewed on Feb 4, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F1%2F2026&endDate=3%2F2%2F2026&selected=3608197&PinnedHotelID=3608197&HadPinnedHotel=true&regionId=6286134)

![Bocas Paradise Hotel](https://images.trvl-media.com/lodging/9000000/8130000/8124800/8124781/f0ebf030_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Bocas Paradise Hotel

Bocas Town Bocas del Toro 

Fully refundableReserve now, pay when you stay

$84 nightly

$92 total

Mar 12 - Mar 13

Total with taxes and fees

8.8/10 Excellent! (122 reviews)

Clean room andvstaff wasngood.

Reviewed on Jan 19, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F12%2F2026&endDate=3%2F13%2F2026&selected=8124781&PinnedHotelID=8124781&HadPinnedHotel=true&regionId=6286134)

![Cosmic Crab Resort](https://images.trvl-media.com/lodging/19000000/18920000/18918800/18918788/699d1e4d_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Cosmic Crab Resort

Carenero Island Trail Bocas del Toro Bocas del Toro

$68 nightly

$76 total

Feb 19 - Feb 20

Total with taxes and fees

7.8/10 Good! (128 reviews)

We received a room upgrade due to being assigned the wrong room upon arrival. The room was brand new and large with a comfortable bed and huge bathroom. The staff was very friendly and helpful. The restaurant meals were excellent with good portions. And the pool with the swim up bar was a welcome ...

Reviewed on Dec 24, 2025

[](https://expedia.com/Hotel-Search?startDate=2%2F19%2F2026&endDate=2%2F20%2F2026&selected=18918788&PinnedHotelID=18918788&HadPinnedHotel=true&regionId=6286134)

[See all 304 properties in Cayos Zapatilla](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F11%2F2026&endDate=2%2F12%2F2026&regionId=6286134)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Cayos Zapatilla Vacation Packages

## Cayos Zapatilla Essential Information

| Language        | Spanish                     |
| --------------- | --------------------------- |
| Currency        | Panamanian balboas          |
| Local Welcome   | ¡Hola!                      |
| Local Goodbye   | Adiós                       |
| Closest Airport | Tocumen Intl. Airport (PTY) |

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